Follicular renewal and stemness potency of follicular cells depended of telomerase activity and TERT expression – short review

Abstract Several hypotheses have been proposed, relating to the potential genesis of follicular cells in ovarian niche. Reports using mice as an experimental model suggested that ovaries may contain stem are likely involved formation new follicles adult reproductive life. Over recent years, various types identified and described confirm or disprove existence cells. Most research is focused on granulosa (GCs), which essential for development maturation female germ (oocytes). GCs exhibit features cells, such expression cell markers: OCT-4, Sox-2, Nanog well certain markers mesenchymal including CD29, CD44, CD90, CD105, CD117, CD166. Another discovery favor stemness their ability transdifferentiate towards other lines high telomerase (TERT) activity dividing compartments follicle during its maturation.